Flu more widespread in US; eases off in some areas

NEW YORK (AP) — Flu is now widespread in all but three states as the nation grapples with an earlier-than-normal season. But there was one bit of good news Friday: The number of hard-hit areas declined.

The flu season in the U.S. got under way a month early, in December, driven by a strain that tends to make people sicker. That led to worries that it might be a bad season, following one of the mildest flu seasons in recent memory.

The latest numbers do show that the flu surpassed an "epidemic" threshold last week. That is based on deaths from pneumonia and influenza in 122 U.S. cities. However, it's not unusual — the epidemic level varies at different times of the year, and it was breached earlier this flu season, in October and November.

And there's a hint that the flu season may already have peaked in some spots, like in the South. Still, officials there and elsewhere are bracing for more sickness

In Ohio, administrators at Miami University are anxious that a bug that hit employees will spread to students when they return to the Oxford campus next week.

"Everybody's been sick. It's miserable," said Ritter Hoy, a spokeswoman for the 17,000-student school.

Despite the early start, health officials say it's not too late to get a flu shot. The vaccine is considered a good — though not perfect — protection against getting really sick from the flu.

Flu was widespread in 47 states last week, up from 41 the week before, the Centers for Disease Control and Prevention said on Friday. The only states without widespread flu were California, Mississippi and Hawaii.

The number of hard-hit states fell to 24 from 29, where larger numbers of people were treated for flu-like illness. Now off that list: Florida, Arkansas and South Carolina in the South, the first region hit this flu season.

Recent flu reports included holiday weeks when some doctor's offices were closed, so it will probably take a couple more weeks to get a better picture, CDC officials said Friday. Experts say so far say the season looks moderate.

"Only time will tell how moderate or severe this flu season will be," CDC Director Dr. Thomas Frieden said Friday in a teleconference with reporters.

The government doesn't keep a running tally of adult deaths from the flu, but estimates that it kills about 24,000 people in an average year. Nationally, 20 children have died from the flu this season.

Flu vaccinations are recommended for everyone 6 months or older. Since the swine flu epidemic in 2009, vaccination rates have increased in the U.S., but more than half of Americans haven't gotten this year's vaccine.

Nearly 130 million doses of flu vaccine were distributed this year, and at least 112 million have been used. Vaccine is still available, but supplies may have run low in some locations, officials said.

To find a shot, "you may have to call a couple places," said Dr. Patricia Quinlisk, who tracks the flu in Iowa.

In midtown Manhattan, Hyrmete Sciuto got a flu shot Friday at a drugstore. She skipped it in recent years, but news reports about the flu this week worried her.

During her commute from Edgewater, N.J., by ferry and bus, "I have people coughing in my face," she said. "I didn't want to risk it this year."

The vaccine is no guarantee, though, that you won't get sick. On Friday, CDC officials said a recent study of more than 1,100 people has concluded the current flu vaccine is 62 percent effective. That means the average vaccinated person is 62 percent less likely to get a case of flu that sends them to the doctor, compared to people who don't get the vaccine. That's in line with other years.

The vaccine is reformulated annually, and this year's is a good match to the viruses going around.

The flu's early arrival coincided with spikes in flu-like illnesses caused by other bugs, including a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." Those illnesses likely are part of the heavy traffic in hospital and clinic waiting rooms, CDC officials said.

Europeans also are suffering an early flu season, though a milder strain predominates there. China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo have also reported increasing flu.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Some shortages have been reported for children's liquid Tamiflu, a prescription medicine used to treat flu. But health officials say adult Tamiflu pills are available, and pharmacists can convert those to doses for children.

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Associated Press writers Dan Sewell in Cincinnati, Catherine Lucey in Des Moines, and Malcolm Ritter in New York contributed to this report.

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Online:

CDC flu: http://www.cdc.gov/flu/index.htm

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Golden Globes Live Blog: Clinton's 'Lincoln' Moment

Tina Fey and Amy Poehler: The women of the night. Credit: Paul Drinkwater/NBC/AP Photo.

9:52 p.m. ET: Lena Dunham wins best actress in a comedy for “Girls”! She calls Judd Apatow “the greatest honorary ’Girl.’” “This award is for everyone who feels like there wasn’t a place for her,” she says. “This show made a space for me.”

9:50 p.m. ET: Aziz Ansari is pretending the cast of “Downton Abbey” got him high. And Amy Poehler is in George Clooney’s lap. It’s great.

9:46 p.m. ET: “Brave” wins best animated movie.

9:45 p.m. ET: Oh, Sacha Baron Cohen. He’s subbing for Ricky Gervais with an insult-heavy presentation of the nominated animated movies. (Speaking of, where are Fey and Poehler?!)

9:38 p.m. ET: “Homeland” wins again. Claire Danes scores best actress in a TV drama. “I want to thank the other women in this category who are all so badass, so brilliant,” she says. She thanks her costume designer who apparently took her pants out every week while Danes was pregnant last season.

9:35 p.m. ET: The award goes to “Amour,” which picked up a slew of Oscar nominations too.

9:33 p.m. ET: Arnold Schwarzenegger and Sylvester Stallone look hilarious stuffed into suits. They’re presenting the award for best foreign film.

9:27 p.m. ET: It’s a good night for Don Cheadle. His Showtime show “House of Lies” returns for its second season tonight and he just won a Golden Globe for best actor in a TV comedy.

FULL LIST: 2013 Golden Globes Winners

9:23 p.m. ET: Globe for best original screenplay goes to Quentin Tarantino — that’s two trophies so far for “Django Unchained.” He calls the award a “damn surprise” and thanks his friends for listening to him read his scenes. “I don’t want input,” he says. “When I read it to you, I hear it through your ears.”

9:15 p.m. ET: Globe for best supporting actress in a movie (drama) goes to Anne Hathaway for “Les Miserables.” “Blergh,” she says, clearly flustered. “Thanks for that word, Tina.” She also pays tribute to fellow nominee Sally Field for inspiring her to stay in the industry.

Credit: Jordan Strauss/Invision/AP Photo.

9:12 p.m. ET: Best supporting actor in a TV series or movie goes to …  Ed Harris for “Game Change.”

9:06 p.m. ET: Jennifer Lawrence wins best actress in a movie (comedy or musical) for “Silver Linings Playbook.” “Oh what does it say?” she asks, looking at the trophy. “I beat Meryl.” She means Streep, of course.

9:05 p.m. ET: Camera pans to Tommy Lee Jones who is not at all amused by Wiig and Ferrell.

9:03 p.m. ET: Kristen Wiig and Will Ferrell are doing a hilarious bit about how they know absolutely nothing about any of the best actress movie nominees. Of Judy Dench in “Best Exotic Marigold Hotel”: “And she’s on that tractor with the marigolds everywhere.”

9:01 p.m. ET: Poehler gushes over “Hillary’s husband.” Fey is still in drag from her bit earlier. They’re amazing and we want to see more of them.

9:00 p.m. ET: Clinton’s presenting a clip of “Lincoln.” Now this makes sense. “We’re all here tonight because he did it,” he says of Lincoln’s battle to end slavery.

8:59 p.m. ET: What, Bill Clinton’s here?! He gets a standing ovation.

8:55 p.m. ET: Kevin Costner wins for best actor in a miniseries or movie for “Hatfields & McCoys.”

8:48 p.m. ET: Adele scoops up the Globe for best original song for the latest Bond theme, “Skyfall.” Her reaction: “Oh my God! … Honestly, I came for a night out, with my friend Ida, we’re new mums … I literally came for a night out.”

Credit: Jordan Strauss/Invision/AP Photo.

8:44 p.m. ET: “Life of Pi” wins for best original score … but J-Lo’s nude dress steals the spotlight. Just like her nipple almost did at last year’s Oscars.

8:41 p.m. ET: “Argo’s” real life inspiration, Tony Mendez, joined John Goodman to introduce a clip of the film, which is up for five Globes.

8:36 p.m. ET: Well that was awkward. Some sort of camera malfunction messed up Salma Hayek and Paul Rudd’s best TV drama intro. “Homeland” wins! Executive producer Alex Gansa: “Thanks to everyone who’s been watching ‘Homeland,’ and to those who haven’t, allow me to spoil it for you.”

8:33 p.m. ET: Best actor in a TV drama goes to … Damian Lewis for “Homeland.” Considering it’s a fan and critic favorite right now, not a huge surprise.

Credit: Jordan Strauss/Invision/AP Photo.

8:28 p.m. ET: Hollywood Foreign Press Association president Dr. Aida Takla-O’Reilly disses Jeffrey Katzenberg for never learning her name, asks Bradley Cooper to “call me maybe.” Amazing.

8:21 p.m. ET: And Julianne Moore wins for best actress in a miniseries or movie. “Oh my gosh, my children will be so relieved,” she says. She gives a shout out to Tina Fey and Katie Couric — “two people who made a difference in the 2008 election.”

Credit: Kevin WInter/Getty Images.

8:18 p.m. ET: “Game Change” scores best miniseries or movie. Somewhere, Sarah Palin is probably shaking her fist.

8:14 p.m. ET: We’ll use the commercial break to declare that Poehler and Fey had an absolutely amazing opening bit. Bravo.

8:12 p.m. ET: Second award of the night, best supporting actress in TV: Maggie Smith for “Downton Abbey.” According to Poehler and Fey’s drinking game, you should drink take off a piece of clothing now.

RELATED: Poehler and Fey Reveal Their Golden Globes Drinking Game

8:10 p.m. ET: And the award for best supporting actor in a movie goes to … Christoph Waltz for “Django Unchained.” Hint that he’ll win the Oscar for that part too?

8:07 p.m. ET: Fey almost reprised her Sarah Palin impression while into-ing Julianne Moore but appears to have lost it. Dang.

8:05 p.m. ET: Poehler: “Meryl Streep is not here tonight, she has the flu. And I hear she’s amazing in it.”

8:04 p.m. ET: Fey had a great one for Anne Hathaway and “Les Mis”: “I have not seen someone so totally alone and abandoned like that since you were on stage with James Franco at the Oscars.”

8:03 p.m. ET: Poehler on Kathryn Bigelow and the “Zero Dark Thirty” torture controversy: “When it comes to torture, I trust the lady who spend three years married to James Cameron.” WOW.

8:02 p.m. ET: Oh and they’re not going to be offensive like past host Ricky Gervais. Poehler: ”When you run afoul of the Hollywood Foreign Press, they make you host this show two more times.”

8:00 p.m. ET: Fey and Poehler did an outfit change before stepping up to the mic. Poehler threw the first jab of the night: “You can smell the pills from here. ”

7:44 p.m. ET: “Scandal” and “Django Unchained” star Kerry Washington never Googles herself. She feels like it’s bad for her health. Now you know. Also, she looks gorgeous in Miu Miu.

7:40 p.m. ET: @AngiesRightLeg has met its match: Halle Berry struck a leggy pose on the red carpet in an unfortunate one-shoulder gown.

Angie's Right Leg, meet Halle's. Credit: Steve Granitz/Getty Images.

7:33 p.m. ET: It’s an “ER” reunion! George Clooney and Julianna Margulies just hugged on the red carpet.

7:28 p.m. ET: Best song nominee Adele revealed that she actually had to be convinced to write the theme for “Skyfall.” “It’s a big responsibility doing a Bond song,” she said. “I didn’t want to let everybody down by doing it.”

7:19 p.m. ET: Julianne Moore looks stunning in black and white Tom Ford. She’s up for best actress in a TV movie for “Game Change.”

7:18 p.m. ET: “Mad Men” star Jon Hamm on the best part of playing Don Draper: “Well it’s always fun to play drunk, because if you forget your lines you’re just like, ‘Uh, well, I’m in character.’”

PHOTOS: The 2013 Golden Globes Red Carpet

7:15 p.m. ET: Taylor Swift wore a mermaid-cut eggplant gown … and did not at all talk about what happened with her latest boyfriend, Harry Styles. Sigh.

Credit: Credit: Steve Granitz/Getty Images.

7:14 p.m. ET: Hugh Jackman revealed the “horrible” way he shed weight quickly before filming “Les Mis”: “I lost about 35 pounds in 36 hours before the first scene. I didn’t drink any liquids whatsoever.”

7:07 p.m. ET: Another fashion miss: Jennifer Lawrence. It looks like she stole Madonna’s cone bra and cut off the straps.

Credit: Steve Granitz/Getty Images.

7:02 p.m. ET: “Zero Dark Thirty” star Jessica Chastain diverged from the major trends of the night — nude, black and white, and red — in a powder blue Calvin Klein Collection gown. The plunging bodice looks a bit like a sack.

Credit: Steve Granitz/Getty Images.

6:57 p.m. ET: E!’s mani-cam has become a source of contention. While some actresses happily showed off their nails on the tiny red carpet, Aziz Ansari refused to stick his hand in the diorama-like box.

FULL COVERAGE: The 2013 Awards Season

6:56 p.m. ET: Olivia Munn has a new perspective on newsrooms now that she’s on Aaron Sorkin’s “The Newsroom.” “I think [our show] makes other newsrooms seem pretty easygoing,” she said.

6:42 p.m. ET: Julia Louis-Dreyfus said she had a “little tiny piece of cake” to celebrate her birthday. “Look, this is a corset,” she said, pointing to her Vera Wang dress. “I can’t mess around.” Though she’s up for best actress in a TV comedy, she thinks she’ll lose. “I hope that Lena Dunham or Amy Poehler have their speech ready,” she said.

6:38 p.m. ET: Hosts Tina Fey and Amy Poehler are encouraging their guests to get liquored up. “It’s a party and we want it to remain a party,” Fey said. Both have awesome outfits — a strapless black and white gown for Fey and a low cut tuxedo for Poehler.

6:31 p.m. ET: “Girls” star and Globes nominee Lena Dunham said her stylist gave her very specific instructions about adjusting her dress because “my breasts have a tendency to shove my dress to the right.” She looks lovely in chocolate brown, off-the-shoulder gown.

Lena Dunham. Credit: Steve Granitz/Getty Images.

6:28 p.m. ET: Best actress in a TV comedy nominee Zooey Deschanel showed off her film strip nail art on the red carpet. Very Hollywood.

Zooey Deschanel. Credit: Steve Granitz/Getty Images.

6:22 p.m. ET: Another stunning new mom: Megan Fox. She admitted that husband Brian Austin Green picks most of her dresses.

6:16 p.m. ET: The first surprise of Golden Globes: How utterly amazing Claire Danes looks. She gave birth a month ago and has a flat, practically concave stomach. She tried on her red Versace dress for the first time last night but admitted she’s “been in sweatpants for quite a while.” She added, “I hope I don’t leak.”

RELATED: Claire Danes Flaunts Post-Baby Body at the Golden Globes

Claire Danes dressed her insane post-baby body in Versace. Credit: Steve Granitz/Getty Images.

6:14 p.m. ET: Amy Adams, up for best supporting actress for “The Master,” looks angelic in a Marchesa in a color she called ballet pink. “This is mommy at work,” she said to her daughter back at home.

Amy Adams in Marchesa. Credit: Steve Granitz/Getty Images.

6:12 p.m. ET: Julianne Hough opted for a creepy crawly accessory — her earrings are made out of actual beetles.

6:02 p.m. ET: For Julia Louis-Dreyfus, this Globes is extra special — today is her 52nd birthday and she’s up for best actress in a TV comedy for “Veep.” “Today I’m either a year older & I’m gonna lose a Golden Globe OR at least I’m nominated & I’m not dead yet,” she wrote on her WhoSay page.

6:00 p.m. ET: It’s here, the night that Hollywood has been steeling its liver for: The Golden Globe Awards, which are almost always a raucous time because the Hollywood Foreign Press keeps the bar open throughout the ceremony. We’ll be chronicling all the jokes, insults, red carpet highlights — and of course, the winners — right here. Keep refreshing for the latest updates.

PHOTOS: 2013 Golden Globe Nominees

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Russia rejects Assad exit as precondition for Syria deal

MOSCOW/BEIRUT (Reuters) - Russia voiced support on Saturday for international peace envoy Lakhdar Brahimi but insisted Syrian President Bashar al-Assad's exit cannot be a precondition for a deal to end the country's conflict.

Some 60,000 Syrians have been killed during the 21-month-old revolt and world powers are divided over how to stop the escalating bloodshed. Government aircraft bombed outer districts of Damascus on Saturday after being grounded for a week by stormy weather, opposition activists in the capital said.

A Russian Foreign Ministry statement following talks on Friday in Geneva with the United States and Brahimi reiterated calls for an end to violence in Syria, but there was no sign of a breakthrough.

Brahimi said the issue of Assad, who the United States, European powers and Gulf-led Arab states insist must step down to end the civil war, appeared to be a sticking point.

Russia's Foreign Ministry said: "As before, we firmly uphold the thesis that questions about Syria's future must be decided by the Syrians themselves, without interference from outside or the imposition of prepared recipes for development."

Russia has been Assad's most powerful international backer, joining with China to block three Western- and Arab-backed U.N. Security Council resolutions aimed to pressure him or push him from power. Assad can also rely on regional powerhouse Iran.

Russia called for "a political transition process" based on an agreement by foreign powers last June.

Brahimi, who is trying to build on that agreement, has met three times with senior Russian and U.S. diplomats since early December and met Assad in Damascus.

Russia and the United States disagreed over what the June agreement meant for Assad, with Washington saying it sent a clear signal he must go and Russia contending it did not.

Qatar on Saturday made a fresh call for an Arab force to end bloodshed in Syria if Brahimi's efforts fail, according to the Doha-based al Jazeera television.

"It is not a question of intervention in Syria in favor of one party against the other, but rather a force to preserve security," Qatar's Prime Minister and Foreign Minister, Sheikh Hamad bin Jassim al-Thani, said in an al Jazeera broadcast.

CONFLICT INTENSIFIES

Moscow has been reluctant to endorse the "Arab Spring" popular revolts of the last two years, saying they have increased instability in the Middle East and created a risk of radical Islamists seizing power.

Although Russia sells arms to Syria and rents one of its naval bases, the economic benefit of its support for Assad is minimal. Analysts say President Vladimir Putin wants to prevent the United States from using military force or support from the U.N. Security Council to bring down governments it opposes.

However, as rebels gain ground in the war, Russia has given indications it is preparing for Assad's possible exit, while continuing to insist he must not be forced out by foreign powers.

Opposition activists say a military escalation and the hardship of winter have accelerated the death toll.

Rebel forces have acquired more powerful anti-tank and anti-aircraft weapons during attacks on Assad's military bases.

Assad's forces have employed increasing amounts of military hardware including Scud-type ballistic missiles in the past two months. New York-based Human Rights Watch said they had also used incendiary cluster bombs that are banned by most nations.

STALEMATE IN CITIES

The weeklong respite from aerial strikes has been marred by snow and thunderstorms that affected millions displaced by the conflict, which has now reached every region of Syria.

On Saturday, the skies were clear and jets and helicopters fired missiles and dropped bombs on a line of towns to the east of Damascus, where rebels have pushed out Assad's ground forces, the Syrian Observatory for Human Rights said.

The British-based group, which is linked to the opposition, said it had no immediate information on casualties from the strikes on districts including Maleiha and farmland areas.

Rebels control large swathes of rural land around Syria but are stuck in a stalemate with Assad's forces in cities, where the army has reinforced positions.

State TV said government forces had repelled an attack by terrorists - a term it uses for the armed opposition - on Aleppo's international airport, now used as a helicopter base.

Reuters cannot independently confirm reports due to severe reporting restrictions imposed by the Syrian authorities and security constraints.

On Friday, rebels seized control of one of Syria's largest helicopter bases, Taftanaz in Idlib province, their first capture of a military airfield.

Eight-six people were killed on Friday, including 30 civilians, the Syrian Observatory said.

(Writing by Oliver Holmes; Editing by Tom Pfeiffer and Doina Chiacu)

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France braces for massive anti gay marriage protest

PARIS: Tens of thousands are set to march in Paris on Sunday to denounce government plans to legalise same-sex marriage and adoption which have angered many Catholics and Muslims, France's two main faiths.

Leading the charge is sassy phenomenon Frigide Barjot, whose real name is Virginie Tellenne and who has carved a career by creating a bizarre persona and cocking a snook at the establishment.

Her assumed name -- a play on the name of French film star Brigitte Bardot, a sex symbol in the 1960s -- translates as Frigid Loony.

Barjot has become a rallying symbol for the "March for All", articulating the feelings of many of those opposed to the government initiative.

"One cannot say that a child is born from two women," she says -- an argument espoused by opponents to the legislation in a country which is officially a secular republic but overwhelmingly Catholic.

The French parliament is to debate the bill -- one of the key electoral pledges of Socialist President Francois Hollande -- at the end of this month.

Preparations for the rally have gathered pace. Protesters across the country have hired as many as 90 coaches and five high-speed trains to head to Paris. They say they have distributed 4.5 million leaflets championing their cause.

There will be three different marches across the city which will converge near the Eiffel Tower.

Barjot said on Saturday she was expecting "between 200,000 and 300,000 people."

The march comes a day after France ordered tightened security in public buildings and transport as well as in places with large public gatherings after military action against radical Islamists in Mali and Somalia and threats of reprisals by the extremists.

A poll published Friday showed that 52 per cent of the French backed gay marriage but an equal number opposed same-sex adoption.

The head of the French Roman Catholic Church, Cardinal Andre Vingt-Trois, who has been vocal in his opposition of gay marriage, will not attend the protest. Nor will the chief rabbi Gilles Bernheim and Muslim Council head Mohammed Moussaoui take part in the street protests.

Far-right leader Marine Le Pen will also not be attending. Her National Front party is divided over the issue and has authorised those wanting to take part to do so despite officially taking the line that it was not backing the march.

Marchers have been instructed in leaflets not to react to provocation and told to "keep smiling in the face of invective ... seek discussion and if that fails, turn to the forces of law and order."

The controversy over the highly divisive issue gained momentum after the education minister asked Catholic schools to drop a plan to discuss the bill in schools, evoking France's traditional line of separation of the Church and the state.

French Muslim groups are joining in the opposition. The call has been led by the influential Union of French Islamic Organisations (UOIF) which urged co-religionists to join the march.

"This bill, if it passes, will disrupt family and social structures and civil law dangerously and irreparably," it said.

An earlier protest march on November 17 drew more than 100,000 people across France, with some 70,000 rallying in Paris alone.

Justice Minister Christiane Taubira has said the government will stick to the project, irrespective of the magnitude of the protest and has rejected calls for a referendum on the issue.

- AFP/ck

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Punjab family ravaged by Alzheimer’s banks on gene test

NEW DELHI: A curious case from Punjab has rattled not just Kuldeep Kaur and her family but even the experts who have been striving for over a year to solve her case. Kaur, a 32-year-old mother of two, was living a healthy life till September 2011 when she suddenly developed memory loss. She stopped recognizing people, forgot meals and became urinary incontinent — a pattern observed in her family including her father, grandfather, great grandmother and several other blood relatives.

Kaur had been suffering from an extremely rare disease called familial Alzheimer's that runs into families. This was declared two days ago in a genetic test conducted by a research group based in France.

"This is the first time we have come across any such patient. Her 26-year-old brother had approached us two years ago for genetic testing, fearing that he might also suffer from the same fate as his family members. We did some testing but the mutation in gene could not be identified. Finally, a research group in France offered to do the genetic testing for free and the results came in," said Dr Sunita Bijarniya Mahay, metabolic physician and geneticist at the Center of Genetic Medicine, Ganga Ram Hospital.

Now they will do predicting testing on the brother and Kuldeep's blood relatives, Dr Sunita said, to rule out or confirm the possibility of mutation of the same gene in them. "Though there is no cure for familial Alzheimer's, the tests would help them beat the angst. We can also try to manage the positive cases using best post possible medical intervention," she added.

According to Harmohan Singh, Kuldeep's brother, most of their family members could not survive beyond 50 years. "We always thought it was a family curse and would lead to the extermination of our whole generation. But the finding of the gene responsible for the deaths has given us new hope," he said. Singh was eight when his father passed away due to the same disease.

"Kuldeep's condition is also worsening each day. She has developed urinary incontinent and has become very weak. Her children have been the worst sufferers of the tragedy and no one knows what future they have. We are poor and it is really difficult for us to even think of getting the tests done on each family member," he said.

According to Dr I C Verma, director of the center of genetic medicine at Ganga Ram Hospital, India has the largest number of patients having genetic disorders because of large number of births (27 million per year), consanguineous marriages (within relations), high frequency thalessemia and sickle cell disease.

"Prenatal genetic testing, which can help in timely identification of these risk factors, is available at most centers in India. We are now trying to acquire high-end services like Microarray Analysis that can analyse the minutest change in chromosome and next generation sequencing to multiple genes for possible mutation in one go.

"These new technologies will lead to the identification of the cause of intellectual disability, muscle weakness , brain disorders and many other genetic disorders. This will also lead to the development of newer therapies," he said.

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Q&A: Scramble for vaccine as flu season heats up

WASHINGTON (AP) — Missed flu-shot day at the office last fall? And all those "get vaccinated" ads? A scramble for shots is under way as late-comers seek protection from a miserable flu strain already spreading through much of the country.

Federal health officials said Friday that there is still some flu vaccine available and it's not too late to benefit from it. But people may have to call around to find a clinic with shots still on the shelf, or wait a few days for a new shipment.

"We're hearing of spot shortages," said Dr. Thomas Frieden, director of the Centers for Disease Control and Prevention.

Colorado offers an example. Kaiser Permanente, which has 535,000 members in the state, stopped giving flu shots this week. But it expected to resume vaccinations when new shipments arrive, expected this weekend.

Some questions and answers about flu vaccines:

Q: Are we running out of vaccine?

A: It's January — we shouldn't have a lot left. The traditional time to get vaccinated is in the fall, so that people are protected before influenza starts spreading.

Indeed, manufacturers already have shipped nearly 130 million doses to doctors' offices, drugstores and wholesalers, out of the 135 million doses they had planned to make for this year's flu season. At least 112 million have been used so far.

The nation's largest manufacturer, Sanofi Pasteur, said Friday that it still has supplies of two specialty vaccines, a high-dose shot for seniors, and an under-the-skin shot for certain adults, available for immediate shipment. But it also is working to eke out a limited supply of its traditional shots — some doses that it initially hadn't packaged into syringes, said spokesman Michael Szumera. They should be available late this month.

And MedImmune, the maker of the nasal spray vaccine FluMist, said it has 620,000 extra doses available.

Q: Can't they just make more?

A: No. Flu vaccine is complicated to brew, with supplies for each winter made months in advance and at the numbers expected to sell. Although health officials recommend a yearly flu vaccination for nearly everybody, last year 52 percent of children and just 39 percent of adults were immunized. Most years, leftover doses have to be thrown out.

Q: Should I still hunt for a vaccine?

A: It does take two weeks for full protection to kick in. Still, health officials say it's a good idea to be vaccinated even this late, especially for older people, young children and anyone with medical conditions such as heart or lung diseases that put them at high risk of dangerous flu complications. Flu season does tend to be worst in January and February, but it can run through March.

Q: I heard that a new flu strain is spreading. Does the vaccine really work?

A: Flu strains constantly evolve, the reason that people need an updated vaccine every year. But the CDC says this year's is a good match to the types that are circulating, including a new kind of the tough H3N2 strain. That family tends to be harsher than other flu types — and health officials warned last fall that it was coming, and meant this winter would likely be tougher than last year's flu season, the mildest on record.

Q: But don't some people get vaccinated and still get sick?

A: Flu vaccine never is 100 percent effective, and unfortunately it tends to protect younger people better than older ones. But the CDC released a study Friday showing that so far this year, the vaccine appears 62 percent effective, meaning it's working about as well as it has in past flu seasons.

While that may strike some people as low, Frieden said it's the best protection available. "It's a glass 62 percent full," he said. "It's well worth the effort."

Q: What else can I do?

A: Wash your hands often, and avoid touching your eyes, nose and mouth. Viruses can spread by hand, not just through the air. Also, cough in your elbow, not your hand. When you're sick, protect others by staying home.

And people who are in those high-risk groups should call a doctor if they develop symptoms, added CDC spokesman Tom Skinner. They might be prescribed antiviral medication, which works best if given within the first 48 hours of symptoms.

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AP Medical Writers Lindsey Tanner and Mike Stobbe contributed to this report.

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Poisoned Lottery Winner's Kin Were Suspicious

Urooj Khan had just brought home his $425,000 lottery check when he unexpectedly died the following day. Now, certain members of Khan's family are speaking publicly about the mystery -- and his nephew told ABC News they knew something was not right.

"He was a healthy guy, you know?" said the nephew, Minhaj Khan. "He worked so hard. He was always going about his business and, the thing is: After he won the lottery and the next day later he passes away -- it's awkward. It raises some eyebrows."

The medical examiner initially ruled Urooj Khan, 46, an immigrant from India who owned dry-cleaning businesses in Chicago, died July 20, 2012, of natural causes. But after a family member demanded more tests, authorities in November found a lethal amount of cyanide in his blood, turning the case into a homicide investigation.

"When we found out there was cyanide in his blood after the extensive toxicology reports, we had to believe that ... somebody had to kill him," Minhaj Khan said. "It had to happen, because where can you get cyanide?"

In Photos: Biggest Lotto Jackpot Winners

Authorities could be one step closer to learning what happened to Urooj Khan. A judge Friday approved an order to exhume his body at Rosehill Cemetery in Chicago as early as Thursday to perform further tests.

Lottery Winner Murdered: Widow Questioned By Police Watch Video

Moments after the court hearing, Urooj Khan's sister, Meraj Khan, remembered her brother as the kind of person who would've shared his jackpot with anyone. Speaking at the Cook County Courthouse, she hoped the exhumation would help the investigation.

"It's very hard because I wanted my brother to rest in peace, but then we have to have justice served," she said, according to ABC News station WLS in Chicago. "So if that's what it takes for him to bring justice and peace, then that's what needs to be done."

Khan reportedly did not have a will. With the investigation moving forward, his family is waging a legal fight against his widow, Shabana Ansari, 32, over more than $1 million, including Urooj Khan's lottery winnings, as well as his business and real estate holdings.

Khan's brother filed a petition Wednesday to a judge asking Citibank to release information about Khan's assets to "ultimately ensure" that [Khan's] minor daughter from a prior marriage "receives her proper share."

Ansari may have tried to cash the jackpot check after Khan's death, according to court documents, which also showed Urooj Khan's family is questioning if the couple was ever even legally married.

Ansari, Urooj Khan's second wife, who still works at the couple's dry cleaning business, has insisted they were married legally.

She has told reporters the night before her husband died, she cooked a traditional Indian meal for him and their family, including Khan's daughter and Ansari's father. Not feeling well, Khan retired early, Ansari told the Chicago Sun-Times, falling asleep in a chair, waking up in agony, then collapsing in the middle of the night. She said she called 911.

"It has been an incredibly hard time," she told ABC News earlier this week. "We went from being the happiest the day we got the check. It was the best sleep I've had. And then the next day, everything was gone.

"I am cooperating with the investigation," Ansari told ABC News. "I want the truth to come out."

Ansari has not been named a suspect, but her attorney, Steven Kozicki, said investigators did question her for more than four hours.

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Obama, Karzai accelerate end of U.S. combat role in Afghanistan

WASHINGTON (Reuters) - President Barack Obama and Afghan President Hamid Karzai agreed on Friday to speed up the handover of combat operations in Afghanistan to Afghan forces, raising the prospect of an accelerated U.S. withdrawal from the country and underscoring Obama's determination to wind down a long, unpopular war.

Signaling a narrowing of differences, Karzai appeared to give ground in talks at the White House on U.S. demands for immunity from prosecution for any American troops who stay in Afghanistan beyond 2014, a concession that could allow Obama to keep at least a small residual force there.

Both leaders also threw their support behind tentative Afghan reconciliation efforts with Taliban insurgents, endorsing the establishment of a Taliban political office in Qatar in hopes of bringing insurgents to inter-Afghan talks.

Outwardly, at least, the meeting appeared to be something of a success for both men, who need to show their vastly different publics they are making progress in their goals for Afghanistan. There were no signs of the friction that has frequently marked Obama's relations with Karzai.

Karzai's visit came amid stepped-up deliberations in Washington over the size and scope of the U.S. military role in Afghanistan once the NATO-led combat mission concludes at the end of 2014.

"By the end of next year, 2014, the transition will be complete," Obama said at a news conference with Karzai standing at his side. "Afghans will have full responsibility for their security, and this war will come to a responsible end."

The Obama administration has been considering a residual force of between 3,000 and 9,000 troops - far fewer than some U.S. commanders propose - to conduct counterterrorism operations and to train and assist Afghan forces.

A top Obama aide said this week that the administration does not rule out a complete withdrawal after 2014, a move that some experts say would be disastrous for the weak Afghan central government and its fledgling security apparatus.

Obama on Friday left open the possibility of that so-called "zero option" when he several times used the word "if" to suggest that a post-2014 U.S. presence was far from guaranteed.

Insisting that Afghan forces were "stepping up" faster than expected, Obama said Afghan troops would take over the lead in combat missions across the country this spring, rather than waiting until the summer as originally planned. NATO troops will then assume a "support role," he said.

"It will be a historic moment and another step toward full Afghan sovereignty," Obama said.

Obama said final decisions on this year's troop cuts and the post-2014 U.S. military role were still months away, but his comments suggested he favors a stepped-up withdrawal timetable.

There are some 66,000 U.S. troops currently in Afghanistan. Washington's NATO allies have been steadily reducing their troop numbers as well despite doubts about the ability of Afghan forces to shoulder full responsibility for security.

'WAR OF NECESSITY'

Karzai voiced satisfaction over Obama's agreement to turn over control of detention centers to Afghan authorities, a source of dispute between their countries, although the White House released no details of the accord on that subject.

Obama once called Afghanistan a "war of necessity." But he is heading into a second term looking for an orderly way out of the conflict, which was sparked by the September 11, 2001, attacks on the United States by an al Qaeda network harbored by Afghanistan's Taliban rulers.

He faces the challenge of pressing ahead with his re-election pledge to continue winding down the war while preparing the Afghan government to prevent a slide into chaos and a Taliban resurgence once most NATO forces are gone.

Former Senator Chuck Hagel, Obama's nominee to become defense secretary, is likely to favor a sizable troop reduction.

Karzai, meanwhile, is eager to show he is working to ensure Afghans regain full control of their territory after a foreign military presence of more than 11 years.

Asked whether the cost of the war in lives and money was worth it, Obama said: "We achieved our central goal ... or have come very close to achieving our central goal, which is to de-capacitate al Qaeda, to dismantle them, to make sure that they can't attack us again."

He added: "Have we achieved everything that some might have imagined us achieving in the best of scenarios? Probably not. This is a human enterprise, and you fall short of the ideal."

Obama made clear that unless the Afghan government agrees to legal immunity for U.S. troops, he would withdraw them all after 2014 - as happened in Iraq at the end of 2011.

Karzai, who criticized NATO over civilian deaths, said that with Obama's agreement to transfer detention centers and the planned withdrawal of U.S. forces from Afghan villages, "I can go to the Afghan people and argue for immunity" in a bilateral security pact being negotiated.

Addressing students at Georgetown University later in the day, the Afghan leader predicted with certainty that the United States would keep a limited number of troops in Afghanistan after 2014, in part to battle al Qaeda and its affiliates.

"One of the reasons the United States will continue a limited presence in Afghanistan after 2014 in certain facilities in Afghanistan is because we have decided together to continue to fight against al Qaeda," Karzai said. "So there will be no respite in that."

Many of Obama's Republican opponents have criticized him for setting a withdrawal timetable and accuse him of undercutting the U.S. mission by reducing troop numbers too quickly.

Karzai and his U.S. partners have not always seen eye to eye, even though the American military has been crucial to preventing insurgent attempts to oust him.

In October, Karzai accused Washington of playing a double game by fighting the war in Afghan villages instead of going after insurgents who cross the border from neighboring Pakistan.

In Friday's news conference, Karzai did not back down from his previous comments that foreigners were responsible for some of the official corruption critics say is rampant in Afghanistan. But he acknowledged: "There is corruption in the Afghan government that we are fighting against."

Adding to tensions has been a rash of deadly "insider" attacks by Afghan soldiers and police against NATO-led troops training or working with them. U.S. forces have also been involved in a series of incidents that enraged Afghans, including burning Korans, which touched off days of rioting.

(Additional reporting by Roberta Rampton, Mark Felsenthal, Jeff Mason, Phil Stewart, Tabassum Zakaria, David Alexander; Editing by Warren Strobel and Will Dunham)

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Central African rivals agree unity government

LIBREVILLE: Central African Republic rebel groups on Friday signed a ceasefire deal with President Francois Bozize who agreed to set up a government of national unity and call new elections.

The accord was announced after three days of talks in the Gabon capital between the government and Seleka rebels who launched an offensive on December 10.

The rebels swept aside the impoverished country's army, but stopped just short of the capital Bangui.

The government and rebels signed a ceasefire accord. The two sides and Central African Republic's political opposition also signed two political accords allowing for the appointment of a prime minister from the opposition and setting out other power-sharing details, according to the United Nations.

The talks were organized by the Economic Community of Central African States (ECCAS) which had sent troops to the troubled country as Bozize faced mounting pressure.

Chad's President Idriss Deby, current ECCAS head, said the opposition and Bozize should start work on the transitional government "from tomorrow".

Under the accord, Bozize will be allowed to finish his mandate which ends in 2016 but he cannot replace the new prime minister during the transition period. Bozize has said he will not stand for a new term.

The agreement also calls for the withdrawal of "all foreign military forces" except those sent by the ECCAS countries. Seleka made this demand specifically to secure the withdrawal of about 200 South African troops sent in December.

The UN Security Council welcomed the signature of the ceasefire, in a statement, which "emphasized the necessity of an expeditious implementation of these agreements and called on all parties to implement them in good faith."

The 15-nation council "urged all parties to allow safe and unhindered access to peoples in need of humanitarian assistance as quickly as possible" and for all civilians held by armed groups to be released.

The violence in the country of some five million has affected more than 300,000 children, with child soldiers recruited and some girls forced to act as sex slaves, according to UN agencies.

The United Nations withdrew non-essential staff and the dependents of all workers in December as rebels neared Bangui.

The UN humanitarian department, OCHA, has voiced serious concern about the plight of civilians amid reports of widespread looting and violence.

The UN's World Food Programme, which has suspended its operations in the country, says hundreds of tonnes of food have been stolen from warehouses across the country.

Central African Republic has been notoriously unstable since its independence from France in 1960.

Bozize took power in a coup in 2003 and has since won two elections.

The rebels accused Bozize of failing to uphold earlier peace deals and had called for him to face war crimes charges at the International Criminal Court.

They also said he planned to modify the constitution to allow him to seek a third term in 2016.

Up to 500 soldiers from Gabon, Democratic Republic of Congo, Chad and Cameroon were sent after troubles in 2008. These troops have begun to pull out of the country.

Nearly 600 French troops are stationed in Bangui, officially to ensure the safety of the estimated 1,200 French nationals in the country.

- AFP/al

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Carnatic music: Classic collaborations work

CHENNAI: Shannon Donald, who lives in Mumbai, doesn't mind going for a Carnatic concert these days. And that's not because she grew up listening to south Indian classical music. "I love the singing style now," says the singer, who was amazed to see musician Bombay Jayashri being a picture of composure at MTV's Coke Studio a year ago.

"I was a backing vocalist on the episode in which she sang with Bollywood singer Richa Sharma. Though we had a long day, when it came to shooting her parts, she nailed every note effortlessly," says Donald about Jayashri, who was nominated on January 10 for the 2013 Oscars for writing a Tamil song, 'Pi's Lullaby', for Ang Lee's fantasy epic, 'Life of Pi'.

For many like Jayashri, collaborating with artists from other fields is not just about covering more creative ground. Notching up unlikely fans for classical music is one of the benefits that Jayashri and other Carnatic artists treasure while jamming with world musicians.

"After the Coke Studio episode, more people know me and come for my concerts. It's a win-win situation," says Jayashri, who has worked with Egyptian singer Hisham Abbas, done jugalbandis with Hindustani musicians Ronu Majumdar and sung for Bharatanatyam dancer Leela Samson's performances.

"I do collaborations because I like doing new things," says Jayashri. According to fellow artists like flautist S Shashank, it could have been Jayashri's love for experimentation that helped 'Life of Pi' director Ang Lee zero in on her for the Oscar-nominated project.

"I got to work on guitarist John McLaughlin's album 'Floating Point' because I work with world musicians. The album was nominated for a Grammy award in 2009," says the flautist, who will release an album, 'Here and Now', with Danish guitar maestro John Sund.

What draws western musicians is the ability of Indian musicians to improvise, says Shashank who has worked with legendary Spanish guitarist Paco de Lucia and with jazz musicians. Shashank loves the freedom to explore the flute outside the traditional concert format of Carnatic, which is a text-laden system and favours the vocalist. "It is a great learning experience. Also, as India is flooded with film music this is the only way classical musicians, especially instrumentalists, can carve a niche for themselves and establish commercially."

These artists still face the criticism that they are diluting pure music. "When, the late Pandit Ravi Shankar did jugalbandis, he was accused of doing the same. Now, jugalbandis have become the norm," says Jayashri.

To mandolin player U Shrinivas, collaborations mean more recognition for classical music. "My audience is bigger. My students come from all over the world to learn to Carnatic music," he says. And to Shrinivas, who is happy and proud of Jayashri's Oscar nomination, this could well be the best time for Indian classical music.

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